The aim of the different research lines from the Musculoskeletal Pathology Group is the diseases that affect the locomotor system more prevalently. Among these pathologies feature osteoarthritis, osteoporosis, heterotopic ossification, ankylosing spondylitis, gout, etc.
The group research lines can be grouped in 5 large areas of knowledge:
- New pharmacological approaches for osteoarthritis and other rheumatic inflammatory diseases.
- Study and pharmacological modulation of bone metabolism.
- Search for protein and cellular biomarkers for the characterization and diagnosis of heterotopic ossification.
- Pharmacological doping of implants for the surgical approach of pathologies such as osteoarthritis.
- Study of environmental, iatrogenic, or metabolic factors harmful to the musculoskeletal system.
01
New pharmacological approaches for osteoarthritis and other rheumatic inflammatory diseases.
This research line studies the potential repositioning of drugs to control the inflammatory and catabolic joint processes. Similarly, new natural active principles are explored as potential pharmacological tools for the same purpose.
02
Study and pharmacological modulation of bone metabolism.
This research line studies the disruption of osteoblast-adipocyte balance in bone alterations associated with multiple rheumatic diseases. In addition, different therapeutic approaches, as pharmacological repositioning, and other are being investigated to treat these alterations among which heterotopic ossification stands out.
03
Search for protein and cellular biomarkers for the characterization and diagnosis of heterotopic ossification.
This invesgation line is focused in the identification of heterotopic ossification proteic and cell biomarkers that allow characterization and early-diagnose of this disease. Moreover, main abnormal bone growth pathways are studied, as well as potential therapeutic targets to inhibit them.
04
Pharmacological doping of implants for the surgical approach of pathologies such as osteoarthritis.
This invesgation line is focused in the identification of heterotopic ossification proteic and cell biomarkers that allow characterization and early-diagnose of this disease. The aim is to confer new biological properties on implants not developed prevously in clinical practice (future-prospective personalized medicine).
05
Study of environmental, iatrogenic, or metabolic factors harmful to the musculoskeletal system.
This research line studies natural compounds commonly present in highly consumed foods that may have harmful consequences to several locomotor system tissues Moreover, this same approach is performed on drugs that may be harmfully altering the homeostasis of musculoskeletal tissues. Finally, considering the remarkable link between metabolic alterations and multiple musculoskeletal pathologies we study metabolic factors that can exert deleterious effects on musculoskeletal tissues.
